Spatial aesthetics in health settings remain a challenge due to the difficulty in balancing disease prevention, such as the aseptic and ergometric protective needs of clinical hospital design, with health promotion through exposure to beauty. The objective of this work is to identify the importance of the aesthetics of the environment in the treatment of Mental Health, through bibliographic research of qualitative character using Pubmed and Scielo databases, between the years 1996 to 2018, with the key words: Design, Architecture, Art, Mental Health, Humanization, Psychiatry and Aesthetics. It is having as an indication that the aspects that make up the design were extremely important as attributes of humanization because they produce belongingness, respect and specially dignity in the patient. The main variables influencing the aesthetic environment highlighted in this article are: light, sound, color, aroma, texture and shape. The design belongs to the aesthetic-artistic perspective, reinforces the protagonism of the sick human being in detriment of the disease, reinforces the expansion of the concept of care and enhances the patient’s response to treatment. The conclusion reiterates that the multiaxial aspects brought about by the design of environments within hospitals, is in line with the Holistic model of Health, producing Health promotion and positive responses to patients.