Title: Methicilin resistant Staphylococcus aureus nasal colonization and systemic disease: a model based on experience

Biography:

Maria Eugenia Quintana is a young Venezuelan/Spanish Internal Medicine and Infectious diseases Magister, who has worked on emerging/reemerging tropical infections, HIV infection, trauma associated infections and MRSA nasal colonization for the past few years in Caracas, Venezuela. She has also been an invited Professor in Microbiology and Pharmacology at the Central University of Venezuela. Since 2017 she has been living in Barcelona, Spain, where she completed a Fellowship on Septic Trauma and now works on MRSA Colonization continuously. Her research and medical practice have always been passionate about improving social conditions on her environment and generating public policies that can increase quality of life, particularly on tropical regions.

Abstract

Statement of the Problem: Methicilin Resistant Staphylococcus aureus (MRSA) nasal colonization has recently become an issue of public health with major repercussion, for it has been proved to be the cause of multiple complications of a variety of systemic diseases, particularly infectious ones or at least a key factor for their worsening. The purpose of this study is to describe the pathologic mechanisms of this colonization condition and its progress and relationship with systemic disease, based on a model proposed in one of our studies that established its association with Health Care Associated Infections (HCAI) in hospitalized patients at the Internal Medicine Service number 3 of the Vargas Hospital (Caracas), during the period of march-july 2015. Methodology & Theoretical Orientation: a prospective descriptive prevalence study was conducted using a longitudinal design, with an intentional sample of 154 patients selected according to specific criteria. Nasal swab samplings were taken in order to determine nasal colonization by MRSA. We then observed them through time and determined whether or not they developed HCAI during their hospitalization. Afterwards, we proposed a theoretical model of pathogenesis that could explain this behavior of MRSA nasal colonization in HCAI and other systemic diseases. Conclusion & Significance: MRSA nasal colonization represents a clear risk for HCAIs and other systemic diseases. This risk increases in the presence of 1 or more past medical history components: we found a relative risk (RR) of 7 (p <0.05) for MRSA-HCAI and 2 (p <0.05) for history of coexisting conditions-MRSA-HCAI. Establishing a theoretical model for these complex interactions MRSA has with systemic diseases allows understanding Recommendations were made for treatment centers that deal with hospitalized patients with possible MRSA nasal colonization.