Title: Recurrent pregnancy loss (RPL): what we do and what we do not know

Biography:

Ticconi C, graduated in Medicine and Surgery at “La Sapienza” University of Rome. He became specialist in Gynecology and Obstetrics at Tor Vergata University of Rome where currently works as Researcher and Aggregate Professor in Gynecology and Obstetrics. He is author of 221 national and international publications, 78 of which are indexed in Scopus. Main fields of research interest: endocrinology of pregnancy and labor, hCG, implantation, early pregnancy complications, recurrent pregnancy loss. He is reviewer for many relevant journals in Ob/Gyn and is member of the Editorial Board of several Ob/Gyn journals. 

Abstract

Recurrent Pregnancy Loss (RPL), a condition affecting 2-4% of women in reproductive age, is a challenge for modern obstetrics. Indeed, despite extensive investigation has been carried out in this field, defined causes/risk factors for RPL can be detected in only around 50% of women with RPL. The following aspects will be developed on the basis of the current knowledge and of the experience gained by our group on more than 800 managed cases of RPL: 1. Problems of definition; 2. Implantation-related issues with specific application to time-to-pregnancy, eutopic and ectopic pregnancy as well as gestational age of pregnancy loss in women with RPL;  3. Immune contributors to RPL with specific application to autoantibodies; 4. Limitations and possibilities of the current diagnostic workup for RPL;  5. Efficacy of treatments and outcome of subsequent pregnancies in women with RPL; 6. Methodological pitfalls and future directions in research on RPL and in the clinical management of women with RPL.