Title: Synthesis and structure formation in dilute aqueous solution of a chitosan-DNA hybrid

Biography:

Ilyes Safir has completed his PhD at the age of 33 years from Geneva University. Ilyes Safir is having international experience of performing research in materials science, nanosurface, nanotechnology, analytical chemistry. Skilled in preparing accurate nano-layers of thin polymer films, analysis with Atomic Force Microscope (AFM). Performed novel bio-nanostructured micelles/vesicles for drug delivery system.

Abstract

Combination of straight biochemical and organic routes to graft nucleotide sequences to a chitosan backbone. The resulting chitosan-g-ssDNA hybrid self-assembles into submicrometer size structures in dilute aqueous solution as assessed by atomic force and electron microscopy imaging. The hypothesis of self-assembly driven by chemical incompatibility between the amphiphilic chitosan and nucleic acid grafts is supported further by stability of the self-assembly against ionic strength and pH variations.