Introduction: This was a descriptive retrospective study done to analyze, compare and contrast the demographic, clinical and pathological data of odontogenic tumors, cysts and maxillofacial bone tumors seen at Tikur Anbesa Hospital, Pathology department from Sept.2013-Oct.2018. These were analyzed for age, gender, site of tumor as well as histopathologic type using the 2017 World Health Organization classification system. From a total of 132 cases reviewed, only 107 were having complete records suitable for the study. 59 of the study subjects were males while remaining 48 were female. 60(56.1%) of cases were benign, 16 were malignant and the rest 31 were non neoplastic. From the nonneoplastic cases,(87%) of the cases were odontogenic cysts most commonly occurring on maxilla (63%). The commonest benign odontogenic tumor was ameloblastoma (25%) with mean age of occurrence being 28.8 years and M: F ratio of 1.14:1. Majority occurred on the mandible 14(93.3%). Ossifying fibroma (20%) was the 2nd commonest benign lesion. 8 cases (50%) from the total malignant lesions were of osteosarcoma and primary intraosseous squamous cell carcinoma. 

Conclusion: Odontogenic tumors, cysts and maxillofacial bone lesions show a definite geographic variation. In our study, ameloblastomas were the most frequent odontogenic tumor similar to other African studies but with a slightly younger age of presentation followed by benign fibroosseous lesions which was in contrary to most literatures.