Title: Role of Serum Allograft Inflammatory Factor-1 (AIF-1) In Egyptian Type 2 Diabetic Patients with Atherosclerosis

Biography:

Dr Gihane Khalil professor of Chemical pathology . Medical Research Institute. Alexandria University .Egypt. I am very interested in the field of diabetes management . I have many publications in the field of  diabetes ,obesity, insulin resistance as well as breast cancer research. I supervised many thesis concerened with diabetes and obesity.

Abstract

Diabetes mellitus (DM) is a powerful and independent risk factor for cardiovascular disease. The atherosclerosis process in diabetes is indistinguishable from that of the nondiabetic population, but it begins earlier and is often more extensive and more severe. AIF-1 promotes chemotaxis, spreading and migration of macrophages and vascular smooth muscle cells (VSMCs) which suggest a role of AIF-1 in the atherosclerotic plaque formation.Thus,This study determines the role of AIF-1 In the Egyptian Type 2 Diabetic Patients with Atherosclerosis. The level of AIF-1 was significantly higher in the diabetic atherosclerotic groups when compared to the control group (p=0.000). In diabetic atherosclerotic patients group, there was a significant positive correlation between CIMT and AIF-1 (r=0.468, p= 0.000) , denoting the possible role of elevated serum AIF-1 level  in atherosclerotic process.Thus, AIF-1 could be used as a marker of  atherosclerosis in diabetic patients.