Cryptosporidiosis has been considered as a serious diarrheal disease, especially in immunodeficient patients, where they failed to clear the infection leading to several consequences of infection (i.e death). The role of cell mediated immunity in clearing the infection was demonstrated by the increased susceptibility of HIV/AIDS patients to infection. To date, no specific treatment has been proven for cryptosporidiosis in immunodeficient patients. The study aimed to evaluate the efficacy of Aloe vera gel for the treatment of cryptosporidiosis in immunocompetent and dexamethasone immunosuppressed mice in comparison to that of nitazoxanide. Mice were orally administrated with Aloe vera gel, in a daily dose of 250 mg/L in drinking water, for 14 consecutive days post infection. Parasitological, molecular and immunological measurements were recorded on the 7th, 14th, 21st and 32nd days post infection. Our in vitro results showed that 250 mg/L of prepared gel achieved the highest parasitic reduction. The body weights of Aloe vera treated mice on the 21st and 32nd day post infection, either in immunocompetent or immunosuppressed groups, were nearly the same as those of their corresponding control groups. Aloe vera gel succeeded in clearing cryptosporidiosis with a percent reduction of 100% in immuno- competent mice and 99.67% in immunosuppressed mice. The anti-inflammatory effect of Aloe vera reduced the levels of IFN-γ, IL-4, -6 and -17. The success of Aloe vera gel, in clearing cryptosporidiosis in immunosuppressed mice, was obvious either from the reduction of Cryptosporidium DNA or the oocysts in stool samples; and from the improvement of histopathological sections.

Diabetes, Global burden of 537 million adults with the continuous increase of its incidence and prevalence, and it is estimated that if the pattern of rising remains the same then after 25 years it will involve 783 million people. Sedentary lifestyle, urbanization, aging population, an increase in obesity ratio being the highest risk factor. Such an increase in prevalence becomes challenging for health care practitioners to manage every patient on an individualized basis. Currently, Diabetes care is facing many challenges, and to overcome these challenges, there was a need for increased communication between clinicians and patients, customization of care, and increased collaboration among them that become helpful in improving health outcomes and preventing diabetes complications Digital health is a convergence of health care and technology in which integration of collected data by using software and apps, the emergence of modern models of care, driven by the ubiquity of mobile devices, provide better information, offer low cost with best possible outcomes. Telemedicine is the “Exchange of medical information with the use of electric communication for improving patient’s health status" according to the American telemedicine association. It is an extended term of medical care remotely by the use of audiovisual communications. It includes the transmission of patient data and its remote interpretation for follow-up along with preventive intervention The fact cannot deny that patient-physician interaction plays an essential role in improving health outcomes and preventing long-term complications. Telemedicine proved its role in Diabetes Management and it promises to become a Novel 21st-century tool for better communication between clinicians and patients in a cost-effective manner.