Title: Metastatic HER-2 Positive breast cancer

Biography:

The pa ent is a single 36 years old woman that her Chief Compliant is change in Right breast skin. Invasive ductal carcinoma is confi rmed by breast biopsy (ER and PR posi ve, highKi67 and HER2 posi ve). Staging work up was conducted and plural eff usion detected that was malignant also abnormal absorp on in manubrium in Bone scan. By star ng the chemotherapy, the oncologist faced to abnormality in the contralateral breast cancer. She was operated and received more local treatment, local recurrence and …. Then when was on an -HER2and Endocrine Therapy brain metastasis were observed in MRI so radiotherapy was chosen. Eventually uncontrolled local recurrence, more than three line of chemotherapy, repeated brain metastasis result in failure in survival.
There are some discussions in these pa ents: • Local treatment for primary in metasta c breast cancer • Radiotherapy in metasta c pa ents who are high risk for local recurrence • Discordancy in IHC result • Management of Brain Metastasis • Sequencing of systemic treatment • Management of local recurrence on chest wall And even more subjects depend on  me and audience concepts. In the nutshell I hope to have an interac ve discussion end to wrap up with some take home messages.
 

Abstract

Nahid Nafi ssi is a Breast oncoplas c Surgeon in Head of Breast department of Iran university of medical science. She is Scien fi c secretary of Breast oncoplas c conference and Member of cancer research center. She published More than 70 ar cles in Breast cancer and More than 10 presenta on in interna onal European congress. She has done More than 2000 Breast cancer surgery in 15 years with registra on and follow up for research Pioneer on intra-opera ve Radiotherapy in Breast cancer surgery.